cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2018.2.10089cardio-104Research ArticleПРАКТИЧЕСКАЯ КАРДИОЛОГИЯ ПРИЛОЖЕНИЕ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ. КЛИНИЧЕСКИЕ СЕМИНАРЫPRACTICAL CARDIOLOGY SUPPLEMENT FOR PRACTISING PHYSICIANS. CLINICAL SEMINARSИСПОЛЬЗОВАНИЕ ПРЕПАРАТА ВЫСОКОКОНЦЕНТРИРОВАННЫХ ЭТИЛОВЫХ ЭФИРОВ ПОЛИНЕНАСЫЩЕННЫХ ЖИРНЫХ КИСЛОТ В ПРОФИЛАКТИКЕ ОСЛОЖНЕНИЙ ПОСЛЕ ПЕРЕНЕСЕННОГО ИНФАРКТА МИОКАРДА. АНАЛИЗ СТОИМОСТЬ-ПОЛЕЗНОСТЬFATTY ACIDS FOR PREVENTION OF COMPLICATIONS AFTER MYOCARDIAL INFARCTION. COST-UTILITY ANALYSISПлавинскийС. Л.PlavinskiiSviatoslav L.s.plavinskij@szgmu.ruБариноваА. Н.BarinovaA. N.noemail@neicon.ruФГБОУ ВО «Северо-Западный государственный медицинский университет им. И. И. Мечникова» Минздрава РоссииРоссияNorth-Western State Medical University named after I. I. MechnikovRussian Federation2018181120185827782Copyright © Kardiomag, 20182018KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/104

Использование высококонцентрированных этиловых эфиров полиненасыщенных жирных кислот (ПНЖК) после инфаркта миокарда (ИМ) и у лиц с сердечной недостаточностью (СН) ассоциировано с меньшей смертностью. Задачей данного исследования явились анализ (с помощью марковской модели) стоимость - полезность применения высококонцентрированных этиловых эфиров ПНЖК после ИМ, а также выяснение, приводит ли их применение к сокращению расходов бюджета в какой-либо группе пациентов. Было установлено, что применение высококонцентрированных этиловых эфиров ПНЖК после ИМ приводит в среднем к увеличению числа сохраненных лет жизни с поправкой на ее качество (QALY) на 0,5 при том, что инкрементный показатель стоимость-полезность составил 105 тыс. руб. за один QALY, а показатель суммарной экономической пользы - 780,5 тыс. руб. В группе лиц, которым препарат назначается для профилактики аритмий после аортокоронарного шунтирования, расходы бюджета снижаются, в зависимости от выбранной базы, на 6-50%.

Use of highly concentrated ethyl esters of polyunsaturated fatty acids after myocardial infarction (MI) and in patients with heart failure was associated with lower mortality. ^e goal of this analysis was to perform cost-utility analysis of the use of highly concentrated ethyl esters of polyunsaturated fatty acids after MI (with help of a Markov model) and to find whether its use in some group of patients led to decrease in budget costs. As a result, we have shown that use of highly concentrated ethyl esters of polyunsaturated fatty acids after MI leads to increase in quality-adjusted life expectancy on 0.5 QALY, with incremental cost-effectiveness ratio of 105 thousand rubles per QALY, and net monetary benefit of 780.5 thousand rubles. In the patient subpopulation that receives highly concentrated ethyl esters of polyunsaturated fatty acids for arrhythmia prevention after coronary artery bypass the estimated decrease of budget cost varies between 6 and 50% depending on denominator used.

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The authors declare that there are no conflicts of interest present.